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XC-12

CAT: 0804-HY-176203Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176203Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XC-12 is an orally active and potent small-molecule CD73 inhibitor (an immune checkpoint) with IC50 values of 12.36 nM and 1.29 nM against soluble and membrane-bound CD73 forms, respectively. XC-12 is promising for research of cancers[1].
UNSPSC
12352005
Target
CD73
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C1NN=C(C=C1N2C[C@@H](CC2)OC3=CC=C(C(C(F)(F)F)=C3)C#N)C(C(N4)=O)=CNC4=O
Molecular Formula
C20H15F3N6O4
Molecular Weight
460.37
References & Citations
[1]Cen L, et al. Discovery of Orally Potent Small-Molecule CD73 Inhibitor for Cancer Immunotherapy. J Med Chem. 2025 May 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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