BJ-13

• Description :

  BJ-13 is a reactive oxygen species (ROS) inducer that can lead to mitochondrial membrane potential collapse and caspase-dependent apoptosis. BJ-13 inhibits the proliferation of SGC-7901, U-87MG, and HepG-2 cancer cells (IC50 values of 15.33, 27.18, and 20.44 nM, respectively) . BJ-13 can be used in the study of gastric cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(N(CC1=CC=C(OC)C=C1)C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=C(C(NNC(C4=CC=C(OC)C=C4)=O)=O)C=C3

• Molecular Formula :

  C33H33N3O8

• Molecular Weight :

  599.63

• References & Citations :

  [1]Zhang J, et al. Design, synthesis and biological evaluation of novel 4- (pyrrolo[2,3-d]pyrimidine-4-yloxy) benzamide derivatives as potential antitumor agents. Bioorg Med Chem Lett. 2021 Feb 1;33:127740.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported