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Difelikefalin-d5

CAT: 0804-HY-17609SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-17609SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Difelikefalin-d5 (CR-845-d5) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR) . Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].
Product Name Alternative
CR-845-d5; FE-202845-d5
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C1(N)CCN(C([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC2=CC=CC=C2)NC([C@@H](CC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])N)=O)=O)=O)=O)CC1)O
Molecular Formula
C36H48D5N7O6
Molecular Weight
684.88
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Steven Fishbane, et al. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients. Kidney Int Rep. 2020 Jan 28;5 (5) :600-610.|[3]Steven Fishbane, et al. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients With Pruritus. N Engl J Med. 2020 Jan 16;382 (3) :222-232.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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