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Difelikefalin

CAT: 0804-HY-17609-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17609-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR) . Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].
CAS Number
1024828-77-0
Product Name Alternative
CR-845; FE-202845
UNSPSC
12352209
Hazard Statement
H302, H312, H332
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/difelikefalin.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(C1(N)CCN(C([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC2=CC=CC=C2)NC([C@@H](CC3=CC=CC=C3)N)=O)=O)=O)=O)CC1)O
Molecular Formula
C36H53N7O6
Molecular Weight
679.85
Precautions
H302, H312, H332
References & Citations
[1]Steven Fishbane, et al. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients. Kidney Int Rep. 2020 Jan 28;5 (5) :600-610.|[2]Steven Fishbane, et al. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients With Pruritus. N Engl J Med. 2020 Jan 16;382 (3) :222-232.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Launched
Isoform
κ Opioid Receptor/KOR

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