Pomalidomide-C9-Br

• Description:

  Pomalidomide-C9-Br is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC EGFR degrader 15 (HY-175839) . PROTAC EGFR degrader 15 is a potent EGFR PROTAC degrader with anti-cancer activity[1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C(N1)CCC(N2C(C(C(NC(CCCCCCCCCBr)=O)=CC=C3)=C3C2=O)=O)C1=O

• Molecular Formula:

  C23H28BrN3O5

• Molecular Weight:

  506.39

• References & Citations:

  [1]Li L, et al. A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation. Bioorg Chem. 2025 Sep;164:108864.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2545963-23-1]