Pomalidomide-C9-Br

• Description :

  Pomalidomide-C9-Br is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC EGFR degrader 15 (HY-175839) . PROTAC EGFR degrader 15 is a potent EGFR PROTAC degrader with anti-cancer activity[1].

• UNSPSC :

  12352005

• Target :

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways :

  PROTAC

• Field of Research :

  Cancer

• Smiles :

  O=C(N1)CCC(N2C(C(C(NC(CCCCCCCCCBr)=O)=CC=C3)=C3C2=O)=O)C1=O

• Molecular Formula :

  C23H28BrN3O5

• Molecular Weight :

  506.39

• References & Citations :

  [1]Li L, et al. A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation. Bioorg Chem. 2025 Sep;164:108864.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2545963-23-1]