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14-3-3σ/ERα stabilizer-2

CAT: 0804-HY-175872Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175872Size:1 Each
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Description
14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a Kd of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research[1].
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Molecular Glues
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Smiles
CC1=C(NC2=C(C3=CC=C(NC(CCl)=O)C=C3F)N=C4N2C=C(C)C=C4)C(C)=CC=C1
Molecular Formula
C24H22ClFN4O
Molecular Weight
436.91
References & Citations
[1]Konstantinidou M, et al. Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex. Nat Commun. 2025 Jul 14;16 (1) :6467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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