HBI-2375

CAT: 0804-HY-175802Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175802Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
HBI-2375 (HYBI-084) is a selective, brain-penetrant and orally active MLL1-WDR5 interaction inhibitor. HBI-2375 inhibits WDR5 with an IC50 of 4.48 nM. HBI-2375 shows inhibition of proliferation in MV4;11 leukemia cells (IC50: 3.17 µM) . HBI-2375 is capable of targeted disruption of histone methyltransferase activity in cancer cells. HBI-2375 can be used for the study of leukemia, glioma and glioblastoma[1][2].
CAS Number
[2982574-79-6]
Product Name Alternative
HYBI-084
UNSPSC
12352005
Target
Histone Methyltransferase; WDR5
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=C(C)C(F)=C(N)C=C1C(NC(C=C(N2C=C(C(N3CCN(C)CC3)=O)N=N2)C(F)=C4)=C4N5C[C@@H](C)N(C)[C@@H](C)C5)=O
Molecular Formula
C29H36ClF2N9O2
Molecular Weight
616.11
References & Citations
[1]Farbod Shojaei, et al. Abstract 2640: HBI-2375, a first-in-class IND ready selective MLL1-WDR5 inhibitor, retains desirable preclinical characteristics in solid tumors and in leukemias to be pursued in clinical studies Free. Cancer Res (2024) 84 (6_Supplement) : 2640.|[2]Coker JA, et al. WD repeat domain 5 (WDR5) inhibitors: a patent review (2016-present) . Expert Opin Ther Pat. 2025 Jan;35 (1) :31-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P991529AGEN-2373
HY-106325-01AA 2379
HY-D2188-01IMP-2373
HY-11054-01TH-237A
HY-162818Antibacterial agent 237
HY-D1005B-01Poloxamer 237 (F87)
HY-W1008852CRBN ligand-237
HY-163808Anticancer agent 237
HY-19634-01YK-3-237
HY-P70606-01Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His)

Alternative Products

CatalogName
MF-0119435-01HBI-2375
Z685615-1PAKTygon Formula 2375 Laboratory Tubing
TRC-H592652-25MGHBI-2376 (Pyrazine 13C415N2)
MBS130853-01Chidamide(CS055; HBI-8000)
TUB044415MTR Tygon 2375 Tubing 2.4x4mm
TUB045015MTR Tygon 2375 Tubing 46.4x9.6mm
TUB044815MTR Tygon 2375 Tubing 4.8x8mm - 15MTR
TUB045415MTR Tygon 2375 Tubing 9.6x12.7mm
NBP3-07600-100ugMouse Monoclonal Cytokeratin 14 Antibody (KRT14/2375)
TUB044615MTR Tygon 2375 Tubing 3.2x6.4mm

Popular Products