Antibacterial agent 237

• UNSPSC Description:

  Antibacterial agent 237 (compound Ru-8) is a bacteriostatic agent for Staphylococcus aureus, with MIC of 0.78-1.56 μg/mL. Antibacterial agent 237 destroys bacterial cell membranes, changes their permeability, and induces bacteria to produce Reactive Oxygen Species, leading to bacterial death without causing drug resistance. Antibacterial agent 237 has low hemolytic toxicity to rabbit red blood cells and Raw 264.7 cells, and has significant antibacterial effects against Staphylococcus aureus in mouse skin wound infection models and Bacillus major larvae infection models[1].

• Target Antigen:

  Bacterial; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/antibacterial-agent-237.html

• Smiles:

  CC(C)(C)C(C=C1)=CC(C2=CC(C(C)(C)C)=CC=[N]23)=[N]1[Ru+2]435([N]6=CC=CC7=C6C([N]5=CC=C8)=C8C9=C7NC(C%10=CC=C(SC%11=NC(C%12=CC=[N+](CC)C=C%12)=CS%11)C=C%10)=N9)[N]%13=CC=C(C(C)(C)C)C=C%13C%14=[N]4C=CC(C(C)(C)C)=C%14.[Cl-].[Cl-].[Cl-]

• Molecular Weight:

  1261.87

• References & Citations:

  [1]Wei Deng , et al. Discovery of quaternized pyridine-thiazole-ruthenium complexes as potent anti-Staphylococcus aureus agents. Eur J Med Chem. 2024 Nov 5:277:116712.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4