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Antibacterial agent 237

CAT: 0804-HY-162818Size: 1 EachDry Ice: NoHazardous: No
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Description
Antibacterial agent 237 (compound Ru-8) is a bacteriostatic agent for Staphylococcus aureus, with MIC of 0.78-1.56 μg/mL. Antibacterial agent 237 destroys bacterial cell membranes, changes their permeability, and induces bacteria to produce Reactive Oxygen Species, leading to bacterial death without causing drug resistance. Antibacterial agent 237 has low hemolytic toxicity to rabbit red blood cells and Raw 264.7 cells, and has significant antibacterial effects against Staphylococcus aureus in mouse skin wound infection models and Bacillus major larvae infection models[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Bacterial; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antibacterial-agent-237.html
Smiles
CC(C)(C)C(C=C1)=CC(C2=CC(C(C)(C)C)=CC=[N]23)=[N]1[Ru+2]435([N]6=CC=CC7=C6C([N]5=CC=C8)=C8C9=C7NC(C%10=CC=C(SC%11=NC(C%12=CC=[N+](CC)C=C%12)=CS%11)C=C%10)=N9)[N]%13=CC=C(C(C)(C)C)C=C%13C%14=[N]4C=CC(C(C)(C)C)=C%14.[Cl-].[Cl-].[Cl-]
Molecular Formula
C65H69Cl3N10RuS2
Molecular Weight
1261.87
References & Citations
[1]Wei Deng , et al. Discovery of quaternized pyridine-thiazole-ruthenium complexes as potent anti-Staphylococcus aureus agents. Eur J Med Chem. 2024 Nov 5:277:116712.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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