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CD28-IN-1

CAT: 0804-HY-175780Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175780Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48 μM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-γ, IL-2 and TNF-α) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research[1].
CAS Number
[1465291-19-3]
UNSPSC
12352005
Target
CD28; IFNAR; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C1N(C)C2=CC=CC(C(OCCC3=C(C)NN=C3C)=O)=C2O1
Molecular Formula
C16H17N3O4
Molecular Weight
315.32
References & Citations
[1]Upadhyay S, et al. Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation. bioRxiv [Preprint]. 2025 Aug 2:2025.07.31.667814.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2

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