CD28-IN-2

• Description :

  CD28-IN-2 is a selective CD28-B7 interaction (IC50: 22.4 μM) inhibitor that binds directly to CD28, with a Kd value of 24.1 μM. CD28-IN-2 inhibits CD28-driven immune activation and blocks T cell costimulation. CD28-IN-2 can be used for the study of antitumor immunity and immune-related disorders[1].

• CAS Number :

  [1240857-57-1]

• UNSPSC :

  12352005

• Target :

  CD28

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  COC1=CC=C(CC(OCC2=CC=C(C=C2)N3C=CC=N3)=O)C=C1F

• Molecular Formula :

  C19H17FN2O3

• Molecular Weight :

  340.35

• References & Citations :

  [1]Upadhyay S, et al. Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation. J Med Chem. 2025;68 (23) :25112-25125.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported