CD28-IN-2

CAT: 0804-HY-179648Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179648Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD28-IN-2 is a selective CD28-B7 interaction (IC50: 22.4 μM) inhibitor that binds directly to CD28, with a Kd value of 24.1 μM. CD28-IN-2 inhibits CD28-driven immune activation and blocks T cell costimulation. CD28-IN-2 can be used for the study of antitumor immunity and immune-related disorders[1].
CAS Number
[1240857-57-1]
UNSPSC
12352005
Target
CD28
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
COC1=CC=C(CC(OCC2=CC=C(C=C2)N3C=CC=N3)=O)C=C1F
Molecular Formula
C19H17FN2O3
Molecular Weight
340.35
References & Citations
[1]Upadhyay S, et al. Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation. J Med Chem. 2025;68 (23) :25112-25125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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