LRK-4189

CAT: 0804-HY-175751Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175751Size:1 Each
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Description
LRK-4189 (Compound 319) is an orally active and selective PIP4K2C PROTAC degrader with a DC50 [1].
CAS Number
[3063346-83-5]
UNSPSC
12352005
Target
PI5P4K; PROTACs
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1CC[C@@H](C(N1)=O)NC2=CC=C(C(F)=C2)N3CCN(CC3)[C@H]4CC[C@@H](CC4)C(N[C@H]5CC[C@@H](CC5)NC6=NC(C7=CC=CC(N8C=CC=CC8=O)=C7)=C(C=N6)F)=O
Molecular Formula
C43H49F2N9O4
Molecular Weight
793.90
References & Citations
[1]Krista Goodman, et al. Discovery of LRK-4189, a first-in-class degrader of the lipid kinase PIP4K2C for the treatment of Microsatellite Stable (MSS) Colorectal Carcinoma. ACS. 2025 Aug 20.|[2]Good A, et al. Inhibitors and degraders of pip4k protein. WO2024233846A1. 2024-11-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI5P4Kγ

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