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AZD0233

CAT: 0804-HY-175746-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175746-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD0233 is an orally active CX3CR1 antagonist. AZD0233 modulates the CX3CR1/CX3CL1 signaling axis via immunomodulatory effects. AZD0233 has improved physicochemical properties, metabolic stability, low toxicity and CYP inhibition. AZD0233 improves cardiac function and reduces macrophages and fibrotic scar in mice model of dilated cardiomyopathy. AZD0233 can be used for cardiovascular diseases like dilated cardiomyopathy research[1].
CAS Number
3036141-78-0
UNSPSC
12352005
Target
CX3CR1
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
98.66
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
COC1=CC(F)=C(C=N1)[C@@H](CC2=NC(NS(C)(=O)=O)=NC(N[C@H](CC(C)C)CO)=N2)C
Molecular Formula
C19H29FN6O4S
Molecular Weight
456.53
References & Citations
[1]Karolina N, et al. AZD0233: An oral CX3CR1 antagonist in development for the treatment of cardiovascular disease. ACS. 2025 Aug 20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

example 46 (isomer 2) [WO2024083933]
CAS Number3036141-78-0
PubChem CID171522487
IUPAC NameN-[4-[(2R)-2-(4-fluoro-6-methoxy-3-pyridinyl)propyl]-6-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-1,3,5-triazin-2-yl]methanesulfonamide
Molecular FormulaC19H29FN6O4S
Molecular Weight456.5
XLogP2.6
Topological Polar Surface Area148
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Heavy Atom Count31
Formal Charge0
Complexity637
SMILES
C[C@H](CC1=NC(=NC(=N1)NS(=O)(=O)C)N[C@H](CC(C)C)CO)C2=CN=C(C=C2F)OC
InChI
InChI=1S/C19H29FN6O4S/c1-11(2)6-13(10-27)22-18-23-16(24-19(25-18)26-31(5,28)29)7-12(3)14-9-21-17(30-4)8-15(14)20/h8-9,11-13,27H,6-7,10H2,1-5H3,(H2,22,23,24,25,26)/t12-,13-/m1/s1
InChIKey
BJHGVSXKHJAFFX-CHWSQXEVSA-N
Chemical Structure
2D Structure
2D structure of example 46 (isomer 2) [WO2024083933]
CAS: 3036141-78-0
CID: 171522487
Formula: C19H29FN6O4S
MW: 456.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.5
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Exact Mass456.19550276
Monoisotopic Mass456.19550276
Topological Polar Surface Area148 Ų
Heavy Atom Count31
Formal Charge0
Complexity637
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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