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AGPAT4-IN-1

CAT: 0804-HY-175646Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175646Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGPAT4-IN-1 (Compound CL26) is a covalent AGPAT4 inhibitor with an IC50 of 795 nM. AGPAT4-IN-1 covalently binds to AGPAT4 at Cys228 and significantly inhibits acyltransferase activity, LPA-to-PA conversion and downstream mTOR/S6K pathways. AGPAT4-IN-1 sensitizes hepatocellular carcinoma (HCC) tumors to Sorafenib and significantly induces apoptosis with a synergistic response. AGPAT4-IN-1 has antitumor activity and reduces tumorigenicity and stemness in HCC xenograft mouse models[1].
CAS Number
2411250-59-2
UNSPSC
12352100
Target
Acyltransferase; Apoptosis; mTOR; Ribosomal S6 Kinase (RSK)
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(CCl)NCC(O1)=CC=C1C(S2)=NC3=C2C=CC=C3
Molecular Formula
C14H11ClN2O2S
Molecular Weight
306.77
References & Citations
[1]Ng KY, et al. AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models. Sci Transl Med. 2025 Jul 30;17 (809) :eadn9472.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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