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AGPAT4-IN-1

CAT: 0013-GTR19273198-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273198-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGPAT4-IN-1 (Compound CL26) is a covalent AGPAT4 inhibitor with an IC50 of 795 nM. It binds covalently to the Cys228 site of AGPAT4, significantly inhibiting acyltransferase activity, the conversion of LPA to PA, and the downstream mTOR/S6K pathway. AGPAT4-IN-1 enhances the sensitivity of hepatocellular carcinoma (HCC) tumors to Sorafenib and significantly induces apoptosis through synergistic effects. This compound exhibits antitumor activity and reduces tumorigenicity and stem cell characteristics in a hepatocellular carcinoma xenograft mouse model.
CAS Number
2411250-59-2
Smiles
O=C (NCC=1OC (=CC1) C2=NC=3C=CC=CC3S2) CCl
Molecular Formula
C14H11ClN2O2S
Molecular Weight
306.76
Storage Conditions
-20°C
Notes
For research use only.

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