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EVT0185

CAT: 0804-HY-175606-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175606-02Size:10 mg
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Description
EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) [1].
CAS Number
2588489-03-4
UNSPSC
12352100
Target
ATP Citrate Lyase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(C)(C)CCCCC1=CC=C(CCCCC(C)(C(O)=O)C)C=C1
Molecular Formula
C22H34O4
Molecular Weight
362.50
References & Citations
[1]Gautam J, et al. ACLY inhibition promotes tumour immunity and suppresses liver cancer. Nature. 2025 Jul 30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-[4-(5-Carboxy-5-methylhexyl)phenyl]-2,2-dimethylhexanoic acid
CAS Number2588489-03-4
PubChem CID155596317
IUPAC Name6-[4-(5-carboxy-5-methylhexyl)phenyl]-2,2-dimethylhexanoic acid
Molecular FormulaC22H34O4
Molecular Weight362.5
XLogP6.2
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Heavy Atom Count26
Formal Charge0
Complexity403
SMILES
CC(C)(CCCCC1=CC=C(C=C1)CCCCC(C)(C)C(=O)O)C(=O)O
InChI
InChI=1S/C22H34O4/c1-21(2,19(23)24)15-7-5-9-17-11-13-18(14-12-17)10-6-8-16-22(3,4)20(25)26/h11-14H,5-10,15-16H2,1-4H3,(H,23,24)(H,25,26)
InChIKey
HMPYTWJWXBNCLQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-[4-(5-Carboxy-5-methylhexyl)phenyl]-2,2-dimethylhexanoic acid
CAS: 2588489-03-4
CID: 155596317
Formula: C22H34O4
MW: 362.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight362.5
XLogP36.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Exact Mass362.24570956
Monoisotopic Mass362.24570956
Topological Polar Surface Area74.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity403
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T212436-01EVT0185

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