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EVT0185

CAT: 0013-GTR19264626-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264626-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. In the liver, it is converted by SLC27A2 into a CoA thioester, which interacts with the CoA binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. It mimics the immune and antitumor effects seen with ACLY gene deletion. Additionally, EVT0185 elevates levels of tumor-infiltrating B cells and the chemokine CXCL13. It is applicable in cancer research, including hepatocellular carcinoma (HCC) .
CAS Number
2588489-03-4
Field of Research
Metabolism Research
Smiles
O=C (O) C (C) (C) CCCCC1=CC=C (C=C1) CCCCC (C (=O) O) (C) C
Molecular Formula
C22H34O4
Molecular Weight
362.50
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-175606-01EVT0185

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