GLPG4970

CAT: 0804-HY-175479-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-175479-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GLPG4970 is a potent, selective and orally active salt-inducible kinase 2/3 (SIK2/SIK3) dual inhibitor with IC50 values of 0.3 nM and 0.7 nM. GLPG4970 has weak inhibition of hERG channel with an IC50 of 29 μM. GLPG4970 can decrease TNFα release and increase IL-10 release GLPG4970 can be used for the researches of inflammation and immunology, such as colitis[1].
UNSPSC
12352005
Target
Interleukin Related; Salt-inducible Kinase (SIK) ; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.6000
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CC(F)(F)F)CCC2=C1C(OC)=CC(C3=CC(C4=CC5=C(C=C4)CC(C)(C)N(C)C5)=CN=C3N)=C2
Molecular Formula
C29H31F3N4O2
Molecular Weight
524.58
References & Citations
[1]Kelgtermans H, et al. Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor. J Med Chem. 2025 Aug 14;68 (15) :16551-16577.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-10; SIK1; SIK2; SIK3

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