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GLPG4970

CAT: 0931-T212381-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212381-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
SIK, Interleukin, TNF
Related Pathways
Immunology/Inflammation, Apoptosis, PI3K/Akt/mTOR signaling
Bioactivity
GLPG4970 is a potent, selective, orally active dual inhibitor of salt-inducible kinases 2 and 3 (SIK2/SIK3), with IC50 values of 0.3 nM and 0.7 nM, respectively. It exhibits weak inhibition of the hERG channel, with an IC50 value of 29 μM. GLPG4970 reduces the release of tumor necrosis factor α (TNFα) and increases the release of interleukin 10 (IL-10) . This compound is applicable for research in inflammation and immunology, such as studies on colitis.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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