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K-833

CAT: 0804-HY-175422Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175422Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K-833 is a GPR119 agonist with EC50 values of 39.8 nM (human), 100nM (mouse), 75.4 nM (rat) and 12.6 nM (dog) . K-833 demonstrates a modest increase in GLP-1 secretion and leads to a synergistic increase in GLP-1 levels when combined with AM-5262 (HY-16619) in acute gut peptide secretion assays in mice. K-833 can be used in studies on weight loss[1].
CAS Number
[2639936-77-7]
UNSPSC
12352005
Target
GPR119
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNCC1CN(C(CC2=CC=C(OCCCC3CCN(C4=NC=C(Cl)C=N4)CC3)C=C2F)=O)C1
Molecular Formula
C30H43ClFN5O7
Molecular Weight
640.14
References & Citations
[1]Moyes CR, et al. Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders. J Med Chem. 2025 Jul 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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