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GCS-12

CAT: 0804-HY-162727Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162727Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GCS-12 is a Th1/2-balanced sulfonamide glycolipid with improved interaction with CD1d. GCS-12 is an agonist for natural killer T (NKT) cell, that induces the secretion of cytokine IFN-γ and IL-4, and exhibits immunomodulatory and anti-tumor activities in mice[1].
UNSPSC
12352211
Target
CD1; IFNAR; Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gcs-12.html
Smiles
O[C@H]1[C@H]([C@H](O[C@@H]([C@@H]1O)OC[C@@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)NC(CCCCCCCCCCCNS(CCCCCCCCCCCC)(=O)=O)=O)CO)O
Molecular Formula
C48H96N2O11S
Molecular Weight
909.35
References & Citations
[1]Wen Y, et al., Rationally Designed Highly Potent NKT Cell Agonists with Different Cytokine Selectivity through Hydrogen-Bond Interaction. J Med Chem. 2024 Jul 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CD1d

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