α4β1 antagonist-1

CAT: 0931-T212327-01Size: 10 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T212327-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Integrin, ERK

Related Pathways

MAPK, Cytoskeletal Signaling

Bioactivity

α4β1antagonist-1 (Compound 4) is a highly selective α4β1 integrin antagonist with an IC50 of 15 nM. It inhibits integrin-mediated cell adhesion and the activation of the ERK1/2 signaling pathway. α4β1antagonist-1 also exhibits partial agonist activity on αMβ2 integrin with an EC50 of 23 nM. This compound shows potential for research in chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis, as well as in cancer.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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α4β1 antagonist-1

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