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GL64

CAT: 0804-HY-175232-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175232-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM) . GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases[1].
CAS Number
488801-10-1
UNSPSC
12352005
Target
Endogenous Metabolite; Nuclear Factor of activated T Cells (NFAT)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Endocrinology
Purity
98.80
Smiles
O=C1C2=CC=CC=C2NC(N1C3=CC=C(C=C3)Cl)C4=CC(OCC5=C(C=C(C=C5)Cl)Cl)=CC=C4
Molecular Formula
C27H19Cl3N2O2
Molecular Weight
509.81
References & Citations
[1]He L, et al. Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis. Sci Adv. 2025 Jul 11;11 (28) :eads3829.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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