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GL64

CAT: 0931-T211819-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211819-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
488801-10-1
Target
Others, Endogenous Metabolite
Related Pathways
Others, Metabolism
Bioactivity
GL64 is a selective agonist of ADGRD1 with an EC50 of 3.98 μM. It shows low selectivity for the subtypes ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4. GL64 activates ADGRD1 by mimicking the satchel sequence. It regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. Both in vivo and in vitro, GL64 effectively inhibits osteoclastogenesis and prevents bone loss. This compound is suitable for research into osteoclast-related diseases.
Smiles
O=C1C=2C=CC=CC2NC(C=3C=CC=C(OCC4=CC=C(Cl)C=C4Cl)C3)N1C5=CC=C(Cl)C=C5
Molecular Formula
C27H19Cl3N2O2
Molecular Weight
509.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-175232-01GL64

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