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PfPK6-IN-1

CAT: 0804-HY-175215Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175215Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC50 of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC50 of 13 μM against β-hematin (βH) . PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial[1].
CAS Number
2417648-94-1
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CN1CCC(C(NC2=CC(OC3=CC=C4C(N(C)C(NC5=CC=C(CN6CCN(CC)CC6)C(C(F)(F)F)=C5)=N4)=C3)=CC=N2)=O)CC1
Molecular Formula
C34H41F3N8O2
Molecular Weight
650.74
References & Citations
[1]Nardella F, et al. Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity. Cell Chem Biol. 2025 Jul 17;32 (7) :926-941.e23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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