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TGF-β2-IN-1

CAT: 0804-HY-175205Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175205Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGF-β2-IN-1 is a selective TGF-β2 inhibitor. TGF-β2-IN-1 exhibits potent antiproliferative effects on HCT-116, Caco-2 and HT-29 with IC50 values of 6.84, 10.21, and 9.47 μM, respectively. TGF-β2-IN-1 inhibits TGF-β2 signaling in a dose-dependent manner by suppressing both receptor and cytokine expression.TGF-β2-IN-1 can be used for the study of colorectal cancer[1].
UNSPSC
12352005
Target
TGF-beta/Smad
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
COC1=CC=CC(/C=N/NC(C2=CC=CC=C2OCC3=CN(N=N3)CC4=CC(Cl)=CC=C4)=O)=C1
Molecular Formula
C25H22ClN5O3
Molecular Weight
475.93
References & Citations
[1]Ay EN, et al. Synthesis, characterization, In vitro and In silico investigations of novel 1,2,3-triazole substituted salicylic acid phenolic hydrazones hybrids targeting TGF-β2 expression in colorectal carcinoma. Eur J Med Chem. 2025 Oct 15;296:117915.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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