TGFβ-IN-2
CAT:
804-HY-146434-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TGFβ-IN-2
- CAS Number: 2387678-02-4
- UNSPSC Description: TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration[1].
- Target Antigen: TGF-beta/Smad
- Type: Reference compound
- Related Pathways: Stem Cell/Wnt;TGF-beta/Smad
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/tgfβ-in-2.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(NC1=CC=C(C=C1)OC2=CC(OC3=CC=CC=C32)=O)CN4CCCCC4
- Molecular Weight: 378.42
- References & Citations: [1]Dexin Deng, et al. Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis. Eur J Med Chem. 2020 Jan 1;185:111790.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported