HexylHIBO (hydrobromide)

• Description :

  HexylHIBO hydrobromide is a potent group I mGluR antagonist with Kbs of 140 μM and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO hydrobromide does not inhibits mGlu2 and mGlu4a. HexylHIBO hydrobromide decreases spontaneous excitatory postsynaptic currents (sEPSCs) in rat[1][2].

• UNSPSC :

  12352005

• Target :

  MGluR

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C1C(CCCCCC)=C(ON1)CC(C(O)=O)N.Br

• Molecular Formula :

  C12H21BrN2O4

• Molecular Weight :

  337.21

• References & Citations :

  [1]Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44 (7) :1051-1059. |[2]Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89 (3) :1308-1316.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR1; mGluR5