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ATF3-IN-1

CAT: 0804-HY-175032-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175032-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke[1].
CAS Number
2952703-90-9
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Purity
96.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCOCC1)OCCCCCCCCCCC2=C(C)C(C(OC)=C(OC)C2=O)=O
Molecular Formula
C24H37NO7
Molecular Weight
451.55
References & Citations
[1]Kong X, et al. Discovery of a potential anti-ischemic stroke agent by suppressing ferroptosis through the ATF3/SLC7A11/GPX4 pathway. Eur J Med Chem. 2025 Oct 15;296:117873.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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