ATF3-IN-1

• Description:

  ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Purity:

  96.30

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N1CCOCC1)OCCCCCCCCCCC2=C(C)C(C(OC)=C(OC)C2=O)=O

• Molecular Formula:

  C24H37NO7

• Molecular Weight:

  451.55

• References & Citations:

  [1]Kong X, et al. Discovery of a potential anti-ischemic stroke agent by suppressing ferroptosis through the ATF3/SLC7A11/GPX4 pathway. Eur J Med Chem. 2025 Oct 15;296:117873.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GPX4

• CAS Number:

  [2952703-90-9]