STAT3-IN-44

• Description:

  STAT3-IN-44 is a potent STAT3 inhibitor with IC50s of 1.84 (C6 cells) and 4.81 μM (A549 cells) . STAT3-IN-44 inhibits STAT3 phosphorylation, downregulates Bcl-2, and upregulates Caspase-3 to promote late-stage apoptosis. STAT3-IN-44 significantly suppresses tumor cell proliferation and migration. STAT3-IN-44 can be used for the study of cancers such as glioma and lung cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; Caspase; STAT

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  COC1=CC(/C=C/C2=CC=C(C=C2)OCC(N3CCN(CC3)CC4=CNC5=C4C=C(C=C5)Cl)=O)=CC(OC)=C1

• Molecular Formula:

  C31H32ClN3O4

• Molecular Weight:

  546.06

• References & Citations:

  [1]Xiao Y, et al. Design, synthesis and evaluation of pterostilbene-indole hybrids as potential anticancer agents. Bioorg Med Chem Lett. 2025 Jun 26;128:130317.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcl-2; Caspase 3; STAT3