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SJL2-1

CAT: 0804-HY-174908Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174908Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJL2-1 is a PRMT5 inhibitor, with an IC50 of 1.56 μM. SJL2-1 suppresses proliferation, migration, and invasion in prostate cancer cells. SJL2-1 promotes apoptosis and blocks the cell cycle at the G0/G1 phase. SJL2-1 can target the binding of PRMT5 in cells and inhibit the methylation and expression of the androgen receptor. SJL2-1 can be used for the study of early androgen-sensitive prostate cancer and advanced castration-resistant prostate cancer (CRPC) [1].
UNSPSC
12352005
Target
11β-HSD; Androgen Receptor; Histone Methyltransferase
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=CN(CC(CN2C(C)C(C=CC=C3)=C3CC2)O)C4=CC=CC=C41
Molecular Formula
C22H26N2O
Molecular Weight
334.45
References & Citations
[1]Diao T, et al. Identification of a Selective Cell-Active Inhibitor of Protein Arginine Methyltransferase 5 (PRMT5) for the Treatment of Prostate Cancer by Structure-Based Virtual Screening. Chem Biol Drug Des. 2025 Jun;105 (6) :e70136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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