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TRIM25 ligand-1

CAT: 0804-HY-174853Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174853Size:1 Each
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Description
TRIM25 ligand-1 (Compound 10) is a covalent ligand. TRIM25 ligand-1 can covalently bind to Cys498 in the PRYSPRY domain of TRIM25 and enhance its auto-ubiquitination activity. TRIM25 ligand-1 is selective for TRIM25 in vitro and in live cells[1].
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
CC1=CC(C(N2CCN(C(CCl)=O)CCC2)=O)=CC=C1C3=CC=CC=C3
Molecular Formula
C21H23ClN2O2
Molecular Weight
370.87
References & Citations
[1]McPhie KA, et al. Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination. Chem Sci. 2025 May 12;16 (23) :10432-10443.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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