NPB-1575

• Description:

  NPB-1575 is a potent, orally active and brain-penetrant anti-inflammatory agent. NPB-1575 mitigates neuroinflammation and resists ferroptosis by activating the IRS2/Nrf2/NF-κB axis. NPB-1575 shows protective effect against cerebral ischemic injury and improves the neurological functional prognosis. NPB-1575 can be used for the study of ischemic stroke[1].

• UNSPSC:

  12352005

• Target:

  Ferroptosis; FOXO; Keap1-Nrf2; NF-κB; NO Synthase; Quinone Reductase

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  OC1=CC(O)=C(C/C=C(C)/C)C(CCC2=CC(O)=C(O)C=C2)=C1

• Molecular Formula:

  C19H22O4

• Molecular Weight:

  314.38

• References & Citations:

  [1]Li XN, et al. NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway. Acta Pharmacol Sin. 2025 Jun 5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [161984-54-9]