NPB

• Description:

  NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM[1].

• Product Name Alternative:

  Saponin

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/npb.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  OC1=C(C(N2CCN(C3=C(Cl)C(Cl)=CC=C3)CC2)C4=CC=CC(C(NC5CCCC5)=O)=C4)C=CC=C1

• Molecular Formula:

  C29H31Cl2N3O2

• Molecular Weight:

  524.48

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Pandey V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018 Oct 30;115 (44) :E10505-E10514.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2247491-97-8]