NPB

• Description :

  NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM[1].

• Product Name Alternative :

  Saponin

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/npb.html

• Purity :

  98.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC1=C(C(N2CCN(C3=C(Cl)C(Cl)=CC=C3)CC2)C4=CC=CC(C(NC5CCCC5)=O)=C4)C=CC=C1

• Molecular Formula :

  C29H31Cl2N3O2

• Molecular Weight :

  524.48

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Pandey V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018 Oct 30;115 (44) :E10505-E10514.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2247491-97-8]