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ARN21929

CAT: 0804-HY-174800-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-174800-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN21929 is a Topoisomerase II inhibitor with an IC50 of 4.5 μM. ARN21929 exhibits excellent kinetic and thermodynamic solubility as well as metabolic stability. However, ARN21929 shows poor antiproliferative activity against A549, DU145, MCF7, HeLa, and A375 cells. ARN21929 can be used in the study of cancer[1].
CAS Number
2230854-98-3
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic; heat to 60°C)
Smiles
FC1=C(C=CC=C1)NC2=NC(C3=CC=NC=C3)=NC4=C2CNCC4
Molecular Formula
C18H16FN5
Molecular Weight
321.35
References & Citations
[1]Brindani N, et al. Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors. Sci Rep. 2025 Jun 4;15 (1) :19618.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(2-fluorophenyl)-2-pyridin-4-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine
CAS Number2230854-98-3
PubChem CID135151057
IUPAC NameN-(2-fluorophenyl)-2-pyridin-4-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine
Molecular FormulaC18H16FN5
Molecular Weight321.4
XLogP2.2
Topological Polar Surface Area62.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity403
SMILES
C1CNCC2=C1N=C(N=C2NC3=CC=CC=C3F)C4=CC=NC=C4
InChI
InChI=1S/C18H16FN5/c19-14-3-1-2-4-16(14)23-18-13-11-21-10-7-15(13)22-17(24-18)12-5-8-20-9-6-12/h1-6,8-9,21H,7,10-11H2,(H,22,23,24)
InChIKey
KTMFKCBSMORHOY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-fluorophenyl)-2-pyridin-4-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine
CAS: 2230854-98-3
CID: 135151057
Formula: C18H16FN5
MW: 321.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight321.4
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass321.13897369
Monoisotopic Mass321.13897369
Topological Polar Surface Area62.7 Ų
Heavy Atom Count24
Formal Charge0
Complexity403
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T210575-01ARN21929

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