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ARN21929

CAT: 0804-HY-174800-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174800-01Size:5 mg
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Description
ARN21929 is a Topoisomerase II inhibitor with an IC50 of 4.5 μM. ARN21929 exhibits excellent kinetic and thermodynamic solubility as well as metabolic stability. However, ARN21929 shows poor antiproliferative activity against A549, DU145, MCF7, HeLa, and A375 cells. ARN21929 can be used in the study of cancer[1].
CAS Number
2230854-98-3
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic; heat to 60°C)
Smiles
FC1=C(C=CC=C1)NC2=NC(C3=CC=NC=C3)=NC4=C2CNCC4
Molecular Formula
C18H16FN5
Molecular Weight
321.35
References & Citations
[1]Brindani N, et al. Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors. Sci Rep. 2025 Jun 4;15 (1) :19618.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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