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APH02174

CAT: 0804-HY-174455Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174455Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APH02174 is a highly selective and orally active IRAK4 PROTAC degrader with the DC50 of 4.01 nM in THP-1 cells. APH02174 blocks inflammatory signals by inhibiting IL-6 release. APH02174 can be used for research on inflammatory conditions such as psoriasis vulgaris and rheumatoid arthritis. (Pink: IRAK4 Ligand ; Blue: CRBN Ligand (HY-45512) ; Black: Linker; CRBN Ligand+Linker (HY-174796) )
CAS Number
3065494-66-5
UNSPSC
12352005
Target
Interleukin Related; IRAK; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OCC1CCN(CC1)C2=CC3=C(C=C2NC(C4=COC5=C4N=CC=C5)=O)CC6(CCN(CC6)C[C@@H]7CC[C@@H](OCC#CC8=C(C(N(C9=O)C%10C(NC(CC%10)=O)=O)=CC=C8)N9C)CC7)O3
Molecular Formula
C49H55N7O8
Molecular Weight
870.00
References & Citations
[1]Wu XW, et al. Discovery of APH02174 as a Highly Selective and Orally Bioavailable IRAK4 Degrader for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Jun 26;68 (12) :12845-12861.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; IRAK4

Alternative Products

CatalogName
T211447-01APH02174

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