CK2-IN-15

• Description:

  CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC50 value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases[1].

• UNSPSC:

  12352005

• Target:

  Casein Kinase; SARS-CoV

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage; Stem Cell/Wnt

• Field of Research:

  Infection

• Smiles:

  O=C(C1=CC=C2C(N=C(NCCCCCCCCNCC3=CC=C(C4=CC=CC=C4)C(Cl)=C3)C5=C2C=NC=C5)=C1)O

• Molecular Formula:

  C34H35ClN4O2

• Molecular Weight:

  567.12

• References & Citations:

  [1]Grenier D, et al. Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication. Eur J Med Chem. 2025 May 29;296:117826.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CK2