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2’-Oxo Ifosfamide-d4

CAT: 0804-HY-17419S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17419S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2’-Oxo Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].
CAS Number
1329497-14-4
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker; Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
C(CCl)(=O)N1P(NCCCl)(=O)OCC(C1([2H])[2H])([2H])[2H]
Molecular Formula
C7H9D4Cl2N2O3P
Molecular Weight
279.09
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[3]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[4]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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