MerTK-IN-2

• Description :

  MerTK-IN-2 (compound 15f) is an orally active MerTK inhibitor with an IC50 of 37.5 nM. MerTK-IN-2 can induce apoptosis. MerTK-IN-2 has antitumor activity with IC50 values of 1.79, 18.32, and 2.18 μM for human ovarian cancer cells A2780, breast cancer cells MDA-MB-231, and colon cancer cells HCT116, respectively[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; TAM Receptor

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  FC(C=C1)=CC=C1NC2=NC(NC3CCC(O)CC3)=C(C4=CC=CC(C#N)=N4)C=N2

• Molecular Formula :

  C22H21FN6O

• Molecular Weight :

  404.44

• References & Citations :

  [1]Yang J, et al. Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities. Bioorg Chem. 2025 Jul 15;162:108591.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported