RegisterLogin

SNT-8370

CAT: 0804-HY-173596Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173596Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SNT-8370 is an orally active inhibitor of VAP-1 (IC50: 10 nM) and myeloperoxidase (MPO) (IC50: 17 nM), with >100-1000 fold more potency for VAP-1 and MPO versus other mammalian (per) oxidases. SNT-8370 inhibits MPO-mediated LDL lipid peroxidation. SNT-8370 inhibits leukocyte infiltration in lung injury models of acute inflammation. SNT-8370 is an anti-inflammatory agent, and can be used for research of inflammatory disorders[1].
UNSPSC
12352005
Target
Glutathione Peroxidase; VAP-1
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(N=CN2)N(CC3=CC=CC(OC/C(CN)=C/F)=C3)C(N1)=S
Molecular Formula
C16H16FN5O2S
Molecular Weight
361.39
References & Citations
[1]Glaros E, et al. Targeting vascular adhesion protein-1 and myeloperoxidase with a dual inhibitor SNT-8370 in preclinical models of inflammatory disease. Nat Commun. 2025 Apr 11;16 (1) :3430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-11030SNT-207858
HY-11029-01SNT-207707
HY-170538-01SNT-5382
HY-11030A-01SNT-207858 (free base)
HY-161989-01DZ-837
HY-13967-01AMG 837
HY-W999734CRBN ligand-837
HY-129707AMG 837 (hemicalcium)
HY-13967B-01AMG 837 (calcium hydrate)
HY-13967AAMG 837 (sodium salt)

Alternative Products

CatalogName
T207732-01SNT-8370
MBS387627-01SNT-207707
466196-01SNT-207858
YP-W15707-01Human SNTβ2 (SNTβ2) ELISA Kit
YP-W15708-01Human SNTγ2 (SNTγ2) ELISA Kit
A13124-5SNT-207707 5mg
A13124-100SNT-207707 100mg
A12878-5SNT-207858 5mg
466195SNT-207707-d8
TRC-S080842-100MGSNT-207858-D8

Popular Products