SNT-207858

CAT: 0804-HY-11030Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-11030Size:1 Each
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Description
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].
CAS Number
[1104080-42-3]
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/SNT-207858.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O.[H]Cl
Molecular Formula
C32H45Cl4N5O3
Molecular Weight
689.54
References & Citations
[1]Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4 (3) :e4774.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MC4R

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