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SARS-CoV-2 Mpro-IN-41

CAT: 0804-HY-173485Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173485Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor of COX-2 and SARS-CoV-2 M pro (IC50 values are 9.66 μM and 13.24 μM, respectively) . SARS-CoV-2 Mpro-IN-41 also has a certain inhibitory activity against COX-1 (IC50: 46.11 μM) . SARS-CoV-2 Mpro-IN-41 can significantly inhibit the expression of inflammatory-related cytokines (such as TNF-α, IL-6, IL-1β) and exert anti-inflammatory effects. SARS-CoV-2 Mpro-IN-41 exerts anti-inflammatory and antiviral effects by selectively inhibiting COX-2 and SARS-CoV-2 M pro. SARS-CoV-2 Mpro-IN-41 can be used for anti-inflammatory and anti-coronavirus research[1].
UNSPSC
12352005
Target
COX; SARS-CoV
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(C(C1=NN(C2=CC=C(S(=O)(C)=O)C=C2)C(C3=CC=C(Cl)C=C3)=C1)=C(C)N4C)N4C5=CC=CC=C5
Molecular Formula
C27H23ClN4O3S
Molecular Weight
519.01
References & Citations
[1]Abdelall EKA, et al. Synthesis of new selective agents with dual anti-inflammatory and SARS-CoV-2 Mpro inhibitory activity: Antipyrine-celecoxib hybrid analogues; COX-2, COVID-19 cytokine storm and replication inhibitory activities. Bioorg Chem. 2025 Jun 15;160:108429.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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