VB-85247

• Description :

  VB-85247 is a STING agonist. VB-85247 induces upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as maturation and activation of dendritic cells by activating the STING pathway. VB-85247 can achieve regression of intrabladder tumors and can be used in bladder cancer research[1].

• UNSPSC :

  12352005

• Target :

  CXCR; IFNAR; Interleukin Related; STING; TNF Receptor

• Related Pathways :

  Apoptosis; GPCR/G Protein; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@H](OP4(S[Na])=O)[C@H](F)[C@@H](COP(OCCN5C6=C(N=C5CO4)N=CN=C6)(S[Na])=O)O3

• Molecular Formula :

  C18H18FN9Na2O8P2S2

• Molecular Weight :

  679.45

• References & Citations :

  [1]Prabagar MG, et al. STING Agonist VB-85247 Induces Durable Antitumor Immune Responses by Intravesical Administration in a Non-Muscle-Invasive Bladder Cancer. Cancer Res. 2025 Apr 3;85 (7) :1287-1296.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported