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UNC8212

CAT: 0804-HY-173400Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173400Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC8212 is a TAM kinase inhibitor. UNC8212 has potent inhibitory activity against MERTK and AXL (IC50: 1.5 nM and 1.3 nM, respectively), and also inhibits TYRO3 (IC50: 6.7 nM) . UNC8212 mediates polypharmacological properties by targeting the structurally diverse "back pocket" region of the TAM kinase family. UNC8212 binds tightly to TAM kinases and potently inhibits MERTK and AXL phosphorylation. UNC8212 has anti-tumor effects and can be used in cancer immunotherapy and tumor cell targeting research[1].
UNSPSC
12352005
Target
TAM Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C)C(NC1=CC(C#CC2=CC=C(NC3=NC(N[C@@H]4CC[C@@H](O)CC4)=C(C(NC5CCN(C)CC5)=O)C=N3)C=C2)=NC=C1)=O
Molecular Formula
C34H42N8O3
Molecular Weight
610.75
References & Citations
[1]Hopkins MD, et al. Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors. Eur J Med Chem. 2025 Jun 5;290:117561.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer; Tyro3

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