UNC8212

CAT: 0931-MF-0114688-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0114688-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
UNC8212 is a potent TAM kinase inhibitor. It exhibits strong inhibitory activity against MERTK and AXL, with IC50 values of 1.5 nM and 1.3 nM, respectively, and also inhibits TYRO3 with an IC50 of 6.7 nM. By targeting the structurally diverse "back-pocket" region within the TAM kinase family, UNC8212 modulates polypharmacology characteristics. It binds tightly to TAM kinases and effectively inhibits MERTK and AXL phosphorylation. UNC8212 possesses antitumor properties and is applicable in cancer immunotherapy and target studies for tumor cells.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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