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UNC1215

CAT: 0804-HY-15649-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15649-01Size:5 mg
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Description
UNC1215, a chemical probe, is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor.
CAS Number
[1415800-43-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UNC1215.html
Purity
99.80
Solubility
DMSO : 7.69 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)
Smiles
O=C(C1=CC=C(C(N2CCC(N3CCCC3)CC2)=O)C=C1NC4=CC=CC=C4)N5CCC(N6CCCC6)CC5
Molecular Formula
C32H43N5O2
Molecular Weight
529.72
Precautions
H302, H315, H319, H335
References & Citations
[1]James LI, Barsyte-Lovejoy D, Zhong N, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9 (3) :184-91. doi: 10.1038/nchembio.1157.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS3601729-01UNC1215
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bs-60084C-01UNC1215 --- L3MBTL3 Domain Inhibitor
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