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Ran-IN-1

CAT: 0804-HY-173350-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173350-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ran-IN-1 (Compound M36) is an orally active and selective Ran GTPase inhibitor. Ran-IN-1 binds to the GDP-bound form of Ran (RanGDP) at the allosteric switch II pocket with high specificity, stabilizing the inactive state and reducing the active Ran-GTP population. Ran-IN-1 induces apoptosis and represses DNA repair pathways like HR and NHEJ in epithelial ovarian cancer (EOC) cells. Ran-IN-1 is promising for research of EOC, particularly high-grade serous carcinoma[1].
CAS Number
2301869-11-2
UNSPSC
12352005
Target
Apoptosis; Arf Family GTPase
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Cancer
Smiles
FC1=CC=C(COC[C@@H]2[C@@H](OCC3=CC=C(F)C=C3)[C@@H](OCC4=CC=C(F)C=C4)[C@H](C(N)=S)O2)C=C1
Molecular Formula
C27H26F3NO4S
Molecular Weight
517.56
References & Citations
[1]Boudhraa Z, et al. Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer[J]. bioRxiv, 2025: 2025.03. 02.641080.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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