Ran-IN-1

CAT: 0931-T206660-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T206660-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2301869-11-2

Target

GTPase, Apoptosis

Related Pathways

Apoptosis, GPCR/G Protein

Bioactivity

Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ) . This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.

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O(CC1=CC=C(F)C=C1)[C@H]2[C@@H](OCC3=CC=C(F)C=C3)[C@H](C(N)=S)O[C@@H]2COCC4=CC=C(F)C=C4

Molecular Formula

C27H26F3NO4S

Molecular Weight

517.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-173350-01	Ran-IN-1
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Ran-IN-1

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