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TLK1-IN-1

CAT: 0804-HY-173186Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173186Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC50 of 7.2 μM against TLK1B and a GI50 of 2.7 μM in LNCaP cells. TLK1-IN-1 induces DNA damage and apoptosis in cancer cells, making it a potential candidate for prostate cancer research[1].
UNSPSC
12352005
Target
Ser/Thr Kinase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(Cl)C=C1)CN(N=C2)C(C3=C2C4=CC(Br)=CC=C4N3CCN5CCOCC5)=O
Molecular Formula
C24H23BrClN5O3
Molecular Weight
544.83
References & Citations
[1]Johnson D, et al. Characterization of new non-ATP dependent inhibitors of TLK1 as potential molecules for treating prostate cancer. Bioorg Chem. 2025 May;158:108317.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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