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PSF-IN-2

CAT: 0804-HY-173177-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173177-02Size:10 mg
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Description
PSF-IN-2 (Compound (C) -30) is a PSF inhibitor with an IC50 value of 0.005 pM. PSF-IN-2 exhibits anti-cancer activity, and its IC50 value for inhibiting the proliferation of 22Rv1 cells is 0.5 μM. PSF-IN-2 activates the p53 signaling pathway by inhibiting the binding of PSF to RNA, inducing the expression of related genes, promoting apoptosis, and inhibiting the cell cycle. PSF-IN-2 can be used in cancer research[1].
CAS Number
185418-37-5
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OC2=C(C(C3=CC=C(OC)C=C3)=C1)C=CC(OC)=C2OC
Molecular Formula
C18H16O5
Molecular Weight
312.32
References & Citations
[1]Takayama KI, et al. Inhibition of PSF Activity Overcomes Resistance to Treatment in Cancers Harboring Mutant p53. Mol Cancer Ther. 2025 Mar 4;24 (3) :370-383.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

7,8-dimethoxy-4-(4-methoxyphenyl)-2H-chromen-2-one
CAS Number185418-37-5
PubChem CID888604
IUPAC Name7,8-dimethoxy-4-(4-methoxyphenyl)chromen-2-one
Molecular FormulaC18H16O5
Molecular Weight312.3
XLogP3
Topological Polar Surface Area54
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity452
SMILES
COC1=CC=C(C=C1)C2=CC(=O)OC3=C2C=CC(=C3OC)OC
InChI
InChI=1S/C18H16O5/c1-20-12-6-4-11(5-7-12)14-10-16(19)23-17-13(14)8-9-15(21-2)18(17)22-3/h4-10H,1-3H3
InChIKey
IXWVVHIJMCHVBS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7,8-dimethoxy-4-(4-methoxyphenyl)-2H-chromen-2-one
CAS: 185418-37-5
CID: 888604
Formula: C18H16O5
MW: 312.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight312.3
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass312.09977361
Monoisotopic Mass312.09977361
Topological Polar Surface Area54 Ų
Heavy Atom Count23
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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